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Product name: Methyldopa

Methyldopa

Systematic (IUPAC) name

(S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid

Identifiers

CAS number

555-30-6

ATC code

C02AB01

PubChem

CID 4138

DrugBank

APRD01106

Chemical data

Formula

C10H13NO

Mol. mass

211.215 g/mol

Pharmacokinetic data

Bioavailability

approximately 50%

Metabolism

Hepatic

Half-life

105 minutes

Excretion

Renal for metabolites

Therapeutic considerations

Pregnancy cat.

a drug of choice in PIH

Legal status

Prescription only

Routes

Oral, IV

Methyldopa (L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is a psychoactive drug used as a sympatholytic or antihypertensive. Its use is now deprecated following introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (also known as pregnancy-induced hypertension (PIH)).